247 research outputs found
Stroke care during the COVID-19 pandemic: case numbers, treatments, and mortality in two large German stroke registries
Background and purposeAt the beginning of the SARS-CoV-2 pandemic, an alarming decline in hospitalizations for stroke was reported in several countries, including Germany. We assessed hospitalization numbers and indicators of the quality of stroke care in 2020 during the pandemic containment measures.Materials and methodsThe analysis was based on data of two large stroke quality assurance registries in the north and the south of Germany (QualitĂ€tssicherung Schlaganfall Nordwestdeutschland and Bayerische Arbeitsgemeinschaft fĂŒr QualitĂ€tssicherung in der stationĂ€ren Versorgung). We included 395 hospitals with 467,931 documented cases in 2018â2020. The time interval between admission and thrombolysis, frequency of systemic thrombolysis and intra-arterial therapy (IAT), National Institutes of Health Stroke Scale (NIHSS) score on admission and in-hospital mortality were assessed. Changes in the second (Q2) and fourth (Q4) quarters of 2020 were compared to corresponding quarters in 2019 by chi-squared tests.ResultsHospitalization numbers decreased in the two stroke registries by 8% and 10% in Q2 of 2020 and by 5% and 15% in Q4 of 2020 compared to the same quarters in 2019, respectively. The decline was particularly seen in women and patients with transient ischemic attacks. In cases with cerebral infarction, no increase in NIHSS scores on admission was observed, and the proportion of patients with a time interval between admission and thrombolysis of â€60 min was unchanged. No clear pattern was found in the frequency of systemic thrombolysis and IAT. In one of the registries, in-hospital mortality of patients with cerebral infarction increased in Q2 of 2020 compared to Q2 of 2019.ConclusionCase numbers slightly decreased under pandemic conditions, while our quarterly analysis indicated that the quality of stroke care was largely unchanged throughout the year 2020
study protocol for a randomized controlled trial
Background For the surgical treatment of recurrent primary spontaneous
pneumothoraces (rPSP) different operative therapies are applied to achieve
permanent freedom from recurrence. Methods/design This multicenter clinical
trial evaluates the long-term results of two commonly applied surgical
techniques for the treatment of rPSP. Based on the inclusion and exclusion
criteria, and after obtaining the patientsâ informed consent, participants are
randomized into the two surgical treatment arms: pulmonary wedge resection
plus parietal pleurectomy (WRPP) or parietal pleurectomy alone (PP).
Consecutively, all study participants will be followed up for two years to
evaluate the surgical long-term effect. The primary efficacy endpoint is the
recurrence rate of pneumothorax within 24 months after surgery. The calculated
sample size is 360 patients (nâ=â180 per treatment arm) to prove superiority
of one of the two treatments. So far, 22 surgical sites have submitted their
declaration of commitment, giving the estimated number of participating
patients. Discussion A prospective randomized clinical trial has been started
to compare two established surgical therapies to evaluate the long-term
results regarding recurrence rates. Furthermore, cost of treatment, and
influence on the perioperative morbidity and mortality as well as on quality
of life are analyzed. If the study reveals equivalence for both surgical
techniques, unnecessary pulmonary resections could be avoided
Left Ventricular Remodeling and Myocardial Work: Results From the Population-Based STAAB Cohort Study
Introduction: Left ventricular (LV) dilatation and LV hypertrophy are acknowledged precursors of myocardial dysfunction and ultimately of heart failure, but the implications of abnormal LV geometry on myocardial function are not well-understood. Non-invasive LV myocardial work (MyW) assessment based on echocardiography-derived pressure-strain loops offers the opportunity to study detailed myocardial function in larger cohorts. We aimed to assess the relationship of LV geometry with MyW indices in general population free from heart failure.Methods and Results: We report cross-sectional baseline data from the Characteristics and Course of Heart Failure Stages A-B and Determinants of Progression (STAAB) cohort study investigating a representative sample of the general population of WĂŒrzburg, Germany, aged 30â79 years. MyW analysis was performed in 1,926 individuals who were in sinus rhythm and free from valvular disease (49.3% female, 54 ± 12 years). In multivariable regression, higher LV volume was associated with higher global wasted work (GWW) (+0.5 mmHg% per mL/m2, p < 0.001) and lower global work efficiency (GWE) (â0.02% per mL/m2, p < 0.01), while higher LV mass was associated with higher GWW (+0.45 mmHg% per g/m2, p < 0.001) and global constructive work (GCW) (+2.05 mmHg% per g/m2, p < 0.01) and lower GWE (â0.015% per g/m2, p < 0.001). This was dominated by the blood pressure level and also observed in participants with normal LV geometry and concomitant hypertension.Conclusion: Abnormal LV geometric profiles were associated with a higher amount of wasted work, which translated into reduced work efficiency. The pattern of a disproportionate increase in GWW with higher LV mass might be an early sign of hypertensive heart disease
Social work after stroke: identifying demand for support by recording stroke patients' and carers' needs in different phases after stroke.
BACKGROUND: Previous studies examining social work interventions in stroke often lack information on content, methods and timing over different phases of care including acute hospital, rehabilitation and out-patient care. This limits our ability to evaluate the impact of social work in multidisciplinary stroke care. We aimed to quantify social-work-related support in stroke patients and their carers in terms of timing and content, depending on the different phases of stroke care. METHODS: We prospectively collected and evaluated data derived from a specialized "Stroke-Service-Point" (SSP); a "drop in" center and non-medical stroke assistance service, staffed by social workers and available to all stroke patients, their carers and members of the public in the metropolitan region of Berlin, Germany. RESULTS: Enquiries from 257 consenting participants consulting the SSP between March 2010 and April 2012 related to out-patient and in-patient services, therapeutic services, medical questions, medical rehabilitation, self-help groups and questions around obtaining benefits. Frequency of enquiries for different topics depended on whether patients were located in an in-patient or out-patient setting. The majority of contacts involved information provision. While the proportion of male and female patients with stroke was similar, about two thirds of the carers contacting the SSP were female. CONCLUSION: The social-work-related services provided by a specialized center in a German metropolitan area were diverse in terms of topic and timing depending on the phase of stroke care. Targeting the timing of interventions might be important to increase the impact of social work on patient's outcome
An Update Based on the SCORE-Deutschland Risk Charts
Estimation of absolute risk of cardiovascular disease (CVD), preferably with
population-specific risk charts, has become a cornerstone of CVD primary
prevention. Regular recalibration of risk charts may be necessary due to
decreasing CVD rates and CVD risk factor levels. The SCORE risk charts for
fatal CVD risk assessment were first calibrated for Germany with 1998 risk
factor level data and 1999 mortality statistics. We present an update of these
risk charts based on the SCORE methodology including estimates of relative
risks from SCORE, risk factor levels from the German Health Interview and
Examination Survey for Adults 2008â11 (DEGS1) and official mortality
statistics from 2012. Competing risks methods were applied and estimates were
independently validated. Updated risk charts were calculated based on
cholesterol, smoking, systolic blood pressure risk factor levels, sex and
5-year age-groups. The absolute 10-year risk estimates of fatal CVD were lower
according to the updated risk charts compared to the first calibration for
Germany. In a nationwide sample of 3062 adults aged 40â65 years free of major
CVD from DEGS1, the mean 10-year risk of fatal CVD estimated by the updated
charts was lower by 29% and the estimated proportion of high risk people
(10-year risk > = 5%) by 50% compared to the older risk charts. This
recalibration shows a need for regular updates of risk charts according to
changes in mortality and risk factor levels in order to sustain the
identification of people with a high CVD risk
Chronic hyperglycemia is associated with acute kidney injury in patients undergoing CABG surgery â a cohort study
Background
Chronic hyperglycemia (CHG) with HbA1c as an indicator affects postoperative mortality and morbidity after coronary artery bypass grafting surgery (CABG). Acute kidney injury (AKI) is one of the frequent postoperative complications after CABG impacting short-and long-term outcomes. We investigated the association between CHG and postoperative incidence of AKI in CABG patients with and without history of diabetes mellitus (DM).
Methods
This cohort study consecutively enrolled patients undergoing CABG in 2009 at the department for cardiovascular surgery. CHG was defined as HbA1cââ„â6.0 %. Patients with advanced chronic kidney disease (CKD) were excluded. The incidence of postoperative AKI and its association with CHG was analyzed by univariate and multivariate logistic regression modeling.
Results
Three-hundred-seven patients were analyzed. The incidence of AKI was 48.2 %. Patients with CHG (nâ=â165) were more likely to be female and had greater waist circumference as well as other comorbid conditions, such as smoking, history of DM, CKD, hypertension, pulmonary hypertension, and chronic obstructive pulmonary disease (all pââ€â0.05). Preoperative eGFR, atrial fibrillation (AF), history of DM and CHG were associated with an increased risk of postoperative AKI in univariate analyses. In multivariate modelling, history of DM as well as preoperative eGFR and AF lost significance, while age, CHG and prolonged OP duration (pâ<â0.05) were independently associated with postoperative AKI.
Conclusions
Our results suggest that CHG defined on a single measurement of HbA1cââ„â6.0 % was associated with the incidence of AKI after CABG. This finding might implicate that treatment decisions, including the selection of operative strategies, could be based on HbA1c measurement rather than on a recorded history of diabetes
identifying demand for support by recording stroke patientsâ and carersâ needs in different phases after stroke
Background Previous studies examining social work interventions in stroke
often lack information on content, methods and timing over different phases of
care including acute hospital, rehabilitation and out-patient care. This
limits our ability to evaluate the impact of social work in multidisciplinary
stroke care. We aimed to quantify social-work-related support in stroke
patients and their carers in terms of timing and content, depending on the
different phases of stroke care. Methods We prospectively collected and
evaluated data derived from a specialized âStroke-Service-Pointâ (SSP); a
âdrop inâ center and non-medical stroke assistance service, staffed by social
workers and available to all stroke patients, their carers and members of the
public in the metropolitan region of Berlin, Germany. Results Enquiries from
257 consenting participants consulting the SSP between March 2010 and April
2012 related to out-patient and in-patient services, therapeutic services,
medical questions, medical rehabilitation, self-help groups and questions
around obtaining benefits. Frequency of enquiries for different topics
depended on whether patients were located in an in-patient or out-patient
setting. The majority of contacts involved information provision. While the
proportion of male and female patients with stroke was similar, about two
thirds of the carers contacting the SSP were female. Conclusion The social-
work-related services provided by a specialized center in a German
metropolitan area were diverse in terms of topic and timing depending on the
phase of stroke care. Targeting the timing of interventions might be important
to increase the impact of social work on patientâs outcome
A Self-administered version of the functioning assessment short test for use in population-based studies: A pilot study
Background: The Functioning Assessment Short Test (FAST) is an interviewer-administered scale assessing functional impairment originally developed for psychiatric patients. Objectives: To adapt the FAST for the general population, we developed a self-administered version of the scale and assessed its properties in a pilot study. Methods: The original FAST scale was translated into German via forward and backward translation. Afterwards, we adjusted the scale for self-administered application and inquired participants from two ongoing studies in Germany, 'STAAB' (WĂŒrzburg) and 'BiDirect' (MĂŒnster), both recruiting subjects from the general population across a wide age range (STAAB: 30-79 years, BiDirect: 35-65 years). To assess reliability, agreement of self-assessment with proxy-assessment by partners was measured via intraclass correlation coefficient (ICC) over the FAST score. Construct validity was estimated by conducting correlations with validated scales of depression (PHQ-9), anxiety (GAD-7), and health-related quality of life (SF-12) and regression analyses using these scales besides potentially disabling comorbidities (e.g. Chronic Back Pain (CBP)). Results: Participants (n=54) had a median age of 57.0 years (quartiles: 49.8, 65.3), 46.3% were female. Reliability was moderate: ICC 0.50 (95% CI 0.46-0.54). The FAST score significantly correlated with PHQ-9, GAD-7, and the mental sub-scale of SF-12. In univariable linear regression, all three scales and chronic back pain explained variance of the FAST score. In multivariable analysis, only CBP and the SF-12 remained significant predictors. Conclusion: The German self-administered version of the FAST yielded moderate psychometric properties in this pilot study, indicating its applicability to assess functional impairment in the general population
Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Background and Purpose: Internal carotid artery stenosis (ICAS)â„70% is a leading cause of ischemic cerebrovascular events (ICVEs). However, a considerable percentage of stroke survivors with symptomatic ICAS (sICAS) have <70% stenosis with a vulnerable plaque. Whether the length of ICAS is associated with high risk of ICVEs is poorly investigated. Our main aim was to investigate the relation between the length of ICAS and the development of ICVEs.Methods: In a retrospective cross-sectional study, we identified 95 arteries with sICAS and another 64 with asymptomatic internal carotid artery stenosis (aICAS) among 121 patients with ICVEs. The degree and length of ICAS as well as plaque echolucency were assessed on ultrasound scans.Results: A statistically significant inverse correlation between the ultrasound-measured length and degree of ICAS was detected for sICASâ„70% (Spearman correlation coefficient Ï = â0.57, p < 0.001, n = 51) but neither for sICAS<70% (Ï = 0.15, p = 0.45, n = 27) nor for aICAS (Ï = 0.07, p = 0.64, n = 54). The median (IQR) length for sICAS<70% and â„70% was 17 (15â20) and 15 (12â19) mm (p = 0.06), respectively, while that for sICAS<90% and sICAS 90% was 18 (15â21) and 13 (10â16) mm, respectively (p < 0.001). Among patients with ICAS <70%, a cut-off length of â„16 mm was found for sICAS rather than aICAS with a sensitivity and specificity of 74.1% and 51.1%, respectively. Irrespective of the stenotic degree, plaques of the sICAS compared to aICAS were significantly more often echolucent (43.2 vs. 24.6%, p = 0.02).Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICASâ„70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICASâ„70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results
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